Cindy Boer

Hand osteoarthritis and Matrix-Gla Protein | 129 3.1 dral bone) times, while calculations and statistics were performed as described previ- ously.[19,26] Cartilage samples that yielded fewer than four measurements (n=2) were discarded prior to further analyses. All subchondral bone samples were assessed by eight technical replicates. Acknowledgments The authors are grateful to the study participants, the staff from the Rotterdam Study and the participating general practitioners and pharmacists. We thank Pascal Arp, Mila Jhamai, Marijn Verkerk, Lizbeth Herrera and Marjolein Peters, MSc, and Carolina Medi- na-Gomez, MSc, for their help in creating the GWAS database, and Karol Estrada, PhD, Yurii Aulchenko, PhD, and Carolina Medina-Gomez, MSc, for the creation and analysis of imputed data. We thank Nico Lakenberg, Ruud van der Breggen and Eka Suchiman for their help in preparing DNA and RNA samples. Supplementary Material Additional material is published online only, to view please visit the paper online at the journal website (https://ard.bmj.com/content/76/12/2046.long)