Cindy Boer

Genetics of Osteoarthritis Consortium GWAS Meta-Analyses | 163 4.1 ▲ Figure 1 : Graphical summary of the Genetics of Osteoarthritis Consortium workflow and results. a) Overview of the 11 defined osteoarthritis phenotypes, their relationship with each other and their sample sizes (cases/controls). TKR: total Knee Replacement, THR: total Hip Replacement. b) merged Manhattan- plot of all individual meta-analysis results of all 11 examined osteoarthritis phenotypes. Individual Manhattan plots and QQ-plots can be found in the Supplementary Figure 1. The dashed line represents the genome-wide significance threshold p-value≤1.3x10-8. c) Graphical overview of all genome-significant independent osteoarthritis associated single nucleotide variants (SNVs) and the osteoarthritis phenotypes with which they are associated.