Cindy Boer

Genetics of Osteoarthritis Consortium GWAS Meta-Analyses | 165 4.1 Table 2: Summary statistics of all Genome-Wide Significant Signals in the GO-Consortium Phenotype Other Phe- notypes SNV Chr:pos EA NEA EAF OR 95% CI P-value New Osteoarthrit SNVs  FingerOA rs11588154 1:55301936 T G 0.17 0.8 0.79 - 0.88 6.08x10 -10 HipOA THR rs4411121 1:118757034 T C 0.31 1.1 1.05 - 1.09 2.16x10 -11 THR ipOA, TJR rs1327123 1:184014593 C G 0.35 0.9 0.89 - 0.93 2.44x10 -16 ThumbOA rs11588850 1:227927242 A G 0.82 0.9 0.84 - 0.91 3.53x10 -10 KneeHipOA KneeOA rs74676797 2:633063 A G 0.82 1.1 1.03 - 1.07 6.39x10 -10 THR HipOA rs66989638 2:106689736 A G 0.13 1.1 1.08 - 1.15 3.31x10 -11 THR rs2276749 3:11643465 T C 0.05 0.9 0.82 - 0.90 3.34x10 -09 AllOA rs62242105 3:20630395 A G 0.33 1 0.96 - 0.98 2.93x10 -09 HipOA rs781661531 3:187051013 T C 7x10 -4 0.1 0.05 - 0.21 8.36x10 -11 HipOA rs747952496 3:188311659 A G 4x10 -4 7 3.93 - 12.55 4.91x10 -11 HipOA rs9835230 3:189735461 A G 0.24 1.1 1.04 - 1.09 1.34x10 -09 AllOA SpineOA rs201194999 4:66666895 T C 0.3 0.9 0.85 - 0.92 3.05x10 -09 AllOA rs11729628 4:121584282 T G 0.24 1 0.96 - 0.98 4.74x10 -09 THR rs75686861 4:145621328 A G 0.09 1.1 1.08 - 1.16 3.04x10 -09 KneeOA rs2066928 5:30843787 A G 0.48 1 0.95 - 0.97 1.20x10 -08 THR HipOA rs56132153 5:67825133 A C 0.61 1.1 1.05 - 1.09 3.80x10 -09 HandOA rs1560080 5:115338732 A G 0.83 0.9 0.88 - 0.94 9.61x10 -09 KneeHipOA TJR, AllOA, HipOA, THR rs17615906 5:128018413 T C 0.84 1 0.93 - 0.96 3.76x10 -11 HandOA ThumbOA, KneeOA rs10062749 5:141805088 T G 0.27 1.1 1.06 - 1.11 2.04x10 -09 FingerOA HandOA rs9396861 6:18404133 A C 0.61 1.1 1.09 - 1.17 9.35x10 -11 TJR rs2038740 6:35114542 T C 0.72 0.9 0.93 - 0.96 6.20x10 -10 TJR rs116934101 7:101775597 A G 0.27 1.1 1.04 - 1.08 7.12x10 -09 AllOA rs12667224 7:114024316 A G 0.52 1 0.96 - 0.98 1.66x10 -09 KneeHipOA rs571734653 7:137143697 A C 3x10 -4 6 3.30 - 11.03 5.56x10 -09 TKR rs7787744 7:150521096 A G 0.67 1.1 1.05 - 1.11 1.29x10 -09 TJR rs76340814 9:98321412 A G 0.05 0.9 0.86 - 0.92 1.87x10 -09 THR HipOA, TJR, KneeHipOA rs79895530 9:110416422 T C 0.13 0.9 0.85 - 0.91 3.86x10 -14 HipOA rs7862601 9:118343026 A G 0.62 0.9 0.92 - 0.96 6.19x10 -09 HipOA rs10983775 9:120521100 T C 0.54 1 0.93 - 0.97 4.65x10 -09 HipOA rs10465114 9:129917824 A G 0.22 1.1 1.04 - 1.09 9.04x10 -09 THR HipOA rs3740129 10:73767859 A G 0.46 1.1 1.05 - 1.10 1.70x10 -11 TJR rs10824456 10:78615458 C G 0.58 1 0.94 - 0.97 1.16x10 -08 HandOA THR rs3993110 11:12794530 A C 0.61 1.1 1.06 - 1.11 3.75x10 -11 KneeHipOA rs1631174 11:47974373 A C 0.34 1 1.03 - 1.05 7.28x10 -09 TKR KneeOA rs72979233 11:74355523 A G 0.75 0.9 0.89 - 0.95 2.52x10 -09