Cindy Boer

166 | Chapter 4.1 Phenotype Other Phe- notypes SNV Chr:pos EA NEA EAF OR 95% CI P-value TJR AllOA, KneeHipOA, HipOA, THR rs10831475 11:95796907 A G 0.81 1.1 1.05 - 1.10 5.89x10 -12 KneeHipOA KneeOA, TKR rs10842226 12:23959589 A G 0.42 1 1.03 - 1.06 4.68x10 -10 TKR KneeOA rs7967762 12:48420214 T C 0.16 1.1 1.07 - 1.15 4.41x10 -10 KneeOA rs1426371 12:108629780 A G 0.27 1 0.93 - 0.97 8.86x10 -10 KneeOA rs58973023 13:42959133 A T 0.49 1.1 1.04 - 1.08 4.72x10 -10 TJR rs28929474 14:94844947 T C 0.02 0.8 0.76 - 0.86 1.06x10 -10 THR HipOA rs746239049 15:63067433 D I 0.21 0.9 0.87 - 0.93 8.19x10 -12 KneeOA rs12914479 15:99174828 C G 0.66 1 1.03 - 1.06 7.12x10 -09 KneeOA rs6500609 16:4515334 C G 0.11 0.9 0.91 - 0.96 5.16x10 -09 TJR rs227732 17:54769890 T C 0.3 1.1 1.04 - 1.09 1.61x10 -09 KneeHipOA HipOA, AllOA rs9908159 17:54841961 T C 0.51 1 1.03 - 1.05 4.44x10 -11 AllOA 18:77950448 18:77950448 T C 6x10 -4 3.6 2.35 - 5.60 6.56x10 -09 KneeHipOA rs551471509 19:9943264 T C 6x10 -4 0.2 0.10 - 0.32 1.15x10 -08 HandOA FingerOA rs8112559 19:46390455 C G 0.89 1.1 1.09 - 1.18 7.32x10 -11 TJR rs9981884 21:40585633 A G 0.49 1 0.94 - 0.97 7.93x10 -09 KneeOA rs11705555 22:28206912 A C 0.76 1.1 1.03 - 1.07 3.00x10 -09 THR TJR, HipOA rs12160491 22:38195796 A G 0.71 0.9 0.90 - 0.95 1.28x10 -10 Previously Reported HipOA THR, TJR, AllOA, KneeHipOA rs11164653 1:103464210 T C 0.41 0.9 0.91 - 0.94 2.77x10 -18 AllOA 1:150214028 1:150214028 D I 0.38 1 1.02 - 1.05 8.58x10 -10 TJR rs10797923 1:183901966 T C 0.69 1.1 1.04 - 1.07 6.20x10 -09 TJR KneeHipOA, KneeOA, HipOA, THR rs2605100 1:219644224 A G 0.32 1.1 1.05 - 1.09 4.49x10 -15 KneeHipOA KneeOA rs7581446 2:33423801 T C 0.48 1 0.94 - 0.97 4.87x10 -11 AllOA HipOA, TJR, THR, ThumbOA, KneeHipOA, HandOA rs3771501 2:70717653 A G 0.47 1 1.03 - 1.05 4.05x10 -15 AllOA rs62182810 2:204387482 A G 0.54 1 1.02 - 1.04 3.82x10 -9 THR KneeHipOA, TJR, HipOA rs3774354 3:52817675 A G 0.37 1.1 1.07 - 1.12 1.40x10 -16 TJR TKR, HipOA, AllOA, KneeOA, THR, KneeHipOA rs1530586 4:1760927 T C 0.8 1.1 1.06 - 1.11 3.34x10 -14 THR TJR, HipOA, KneeHipOA, AllOA rs1913707 4:13039440 A G 0.6 1.1 1.06 - 1.11 1.23x10 -13 AllOA HipOA, KneeHipOA rs13107325 4:103188709 T C 0.07 1.1 1.06 - 1.10 3.25x10 -17 KneeHipOA HipOA rs3884606 5:170871074 A G 0.52 1 0.95 - 0.97 8.96x10 -10 Table 2 (continued): Summary statistics of all Genome-Wide Significant Signals in the GO-Consortium