Cindy Boer

Genetics of Osteoarthritis Consortium GWAS Meta-Analyses | 167 4.1 Phenotype Other Phe- notypes SNV Chr:pos EA NEA EAF OR 95% CI P-value HipOA rs79220007 6:26098474 T C 0.93 0.9 0.87 - 0.93 2.22x10 -09 KneeHipOA rs2856821 6:33046742 T C 0.79 1.1 1.03 - 1.06 5.71x10 -09 THR KneeHipOA, HipOA, TJR rs17288390 6:45384018 T C 0.65 0.9 0.90 - 0.94 9.16x10 -13 THR HipOA, TJR rs9475400 6:55638258 T C 0.1 1.2 1.10 - 1.19 1.73x10 -13 THR HipOA, TJR rs12209223 6:76164589 A C 0.11 1.2 1.18 - 1.26 1.92x10 -29 HipOA THR rs111844273 7:18436337 A G 0.02 1.3 1.18 - 1.34 1.05x10 -12 THR HipOA rs143083812 7:128843410 T C 1.1x10 - 3 3.3 2.34 - 4.66 1.11x10 -11 THR HipOA, TJR rs11984666 8:130730280 A C 0.2 0.9 0.87 - 0.92 1.69x10 -15 KneeHipOA KneeOA rs10974438 9:4291928 A C 0.65 1 1.03 - 1.06 7.39x10 -11 KneeHipOA TKR, KneeOA, TJR, AllOA rs72760655 9:116916214 A C 0.33 1.1 1.03 - 1.06 5.97x10 -13 THR HipOA rs1330349 9:117840742 C G 0.59 1.1 1.07 - 1.12 6.47x10 -17 THR HipOA, TJR rs1321917 9:119324929 C G 0.41 1.1 1.08 - 1.13 9.87x10 -19 THR HipOA rs62578126 9:129375338 T C 0.37 0.9 0.90 - 0.94 1.39x10 -12 KneeHipOA TJR rs1517572 11:28829882 A C 0.41 1 1.03 - 1.05 6.79x10 -10 THR HipOA, TJR rs67924081 11:65342981 A G 0.74 1.1 1.07 - 1.12 2.14x10 -13 THR HipOA rs34560402 11:66872320 T C 0.06 0.9 0.82 - 0.90 2.64x10 -10 KneeHipOA rs1149620 11:76506572 A T 0.44 1 0.95 - 0.97 2.87x10 -9 FingerOA rs7294636 12:15054016 A G 0.37 1.2 1.12 - 1.20 2.99x10 -16 THR TJR, KneeHipOA, HipOA rs10843013 12:28025196 A C 0.78 0.9 0.84 - 0.88 2.53x10 -30 THR HipOA rs17120227 12:59289349 T C 0.07 1.2 1.12 - 1.22 7.21x10 -13 KneeHipOA TJR rs7953280 12:94136009 C G 0.5 1 1.03 - 1.06 4.84x10 -12 KneeOA rs753350451 12:123732769 D I 0.2 0.9 0.91 - 0.95 3.36x10 -10 TJR HipOA, THR rs1809889 12:124801226 T C 0.28 1.1 1.05 - 1.09 5.70x10 -14 KneeOA KneeHipOA rs4380013 15:50759428 A G 0.19 1.1 1.04 - 1.08 8.73x10 -10 HandOA KneeOA, TKR, FingerOA, ThumbOA rs11071366 15:58334244 A T 0.61 0.9 0.88 - 0.92 4.88x10 -17 HipOA TJR,THR, KneeHipOA, AllOA rs12908498 15:67366488 C G 0.54 1.1 1.06 - 1.10 1.85x10 -16 KneeHipOA TJR, HipOA, KneeOA rs9940278 16:53800200 T C 0.43 1.1 1.04 - 1.07 1.45x10 -18 KneeOA TKR rs34195470 16:69955690 A G 0.45 1 0.94 - 0.96 3.13x10 -13 AllOA TKR, KneeHipOA, KneeOA rs216175 17:2167690 A C 0.83 1 1.03 - 1.06 2.74x10 -12 THR HipOA rs7212908 17:59654593 A G 0.8 0.9 0.89 - 0.94 1.95x10 -11 THR TJR, HipOA rs2716212 17:67503653 A G 0.62 0.9 0.91 - 0.95 3.56x10 -10 AllOA KneeOA rs10405617 19:10752968 A G 0.32 1 1.02 - 1.04 9.33x10 -11 TJR AllOA rs75621460 19:41833784 A G 0.03 1.2 1.14 - 1.28 2.72x10 -10 THR HipOA, TJR rs4252548 19:55879672 T C 0.02 1.4 1.29 - 1.49 2.49x10 -19 Table 2 (continued): Summary statistics of all Genome-Wide Significant Signals in the GO-Consortium