Cindy Boer

60 | Chapter 1.2 109. Stathis A, Bertoni F. BET proteins as targets for anticancer treatment. Cancer Discov. 2018; 8(1): 24– 36. 110. Wang Z, Zang C, Rosenfeld JA, et al. Combinatorial patterns of histone acetylations and methyla- tions in the human genome. Nat Genet. 2008; 40(7): 897– 903. 111. Lupiáñez DG, Kraft K, Heinrich V, et al. Disruptions of topological chromatin domains cause patho- genic rewiring of gene‐enhancer interactions. Cell. 2015; 161(5): 1012– 25. 112. Spielmann M, Brancati F, Krawitz PM, et al. Homeotic arm‐to‐leg transformation associated with genomic rearrangements at the PITX1 locus. Am J Hum Genet. 2012; 91(4): 629– 35. 113. Bernstein BE, Stamatoyannopoulos JA, Costello JF, et al. The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol. 2010; 28(10): 1045– 8. 114. Rosenbloom KR, Sloan CA, Malladi VS, et al. ENCODE data in the UCSC Genome Browser: year 5 update. Nucleic Acids Res. 2013; 41(Database issue): D56– 63. 115. Relton CL, Davey Smith G. Two‐step epigenetic Mendelian randomization: a strategy for establish- ing the causal role of epigenetic processes in pathways to disease. Int J Epidemiol. 2012; 41(1): 161– 76. 116. Wahl S, Drong A, Lehne B, et al. Epigenome‐wide association study of body mass index and the adverse outcomes of adiposity. Nature. 2017; 541(7635): 81– 6. 117. Trajanoska K, Morris JA, Oei L, et al. Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study. BMJ. 2018; 362: k3225. 118. Zengini E, Hatzikotoulas K, Tachmazidou I, et al. Genome‐wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. Nat Genet. 2018; 50(4): 549– 58. 119. Reynard LN. Analysis of genetics and DNA methylation in osteoarthritis: what have we learnt about the disease? Semin Cell Dev Biol. 2017; 62: 57– 66. 120. Whalen S, Truty RM, Pollard KS. Enhancer‐promoter interactions are encoded by complex genomic signatures on looping chromatin. Nat Genet. 2016; 48(5): 488– 96. 121. Aran D, Sabato S, Hellman A. DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes. Genome Biol. 2013; 14(3): R21. 122. Bonder MJ, Luijk R, Zhernakova DV, et al. Disease variants alter transcription factor levels and methylation of their binding sites. Nat Genet. 2017; 49(1): 131– 8. 123. Rushton MD, Reynard LN, Young DA, et al. Methylation quantitative trait locus analysis of osteoar- thritis links epigenetics with genetic risk. Hum Mol Genet. 2015; 24(25): 7432– 44. 124. den Hollander W, Ramos YFM, Bomer N, et al. Transcriptional associations of osteoarthritis‐medi- ated loss of epigenetic control in articular cartilage. Arthritis Rheumatol. 2015; 67(8): 2108– 16. 125. Bomer N, den Hollander W, Ramos YFM, et al. Underlying molecular mechanisms of DIO2 suscep- tibility in symptomatic osteoarthritis. Ann Rheum Dis. 2015; 74(8): 1571– 9. 126. Medina‐Gomez C, Kemp JP, Dimou NL, et al. Bivariate genome‐wide association meta‐analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus. Nat Com- mun. 2017; 8(1): 121. 127. Castaño‐Betancourt MC, Evans DS, Ramos YFM, et al. Novel genetic variants for cartilage thickness and hip osteoarthritis. PLoS Genet. 2016; 12(10): e1006260. 128. Medina‐Gomez C, Kemp JP, Trajanoska K, et al. Life‐course genome‐wide association study meta‐ analysis of total body BMD and assessment of age‐specific effects. Am J Hum Genet. 2018; 102(1): 88– 102. 129. Wood AR, Esko T, Yang J, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet. 2014; 46(11): 1173– 86. 130. Adhikari K, Fuentes‐Guajardo M, Quinto‐Sánchez M, et al. A genome‐wide association scan impli- cates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation. Nat Commun. 2016;7(May): 1– 11. 131. Huang J, Zhao L, Xing L, Chen D. MicroRNA‐204 regulates Runx2 protein expression and mesenchy- mal progenitor cell differentiation. Stem Cells. 2010; 28(2): 357– 64.

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