Cindy Boer

72 | Chapter 2.1 ▲ Figure 2: Regional association plot for the locus of rs2862851 rs12206662/rs10948155. SNPs are plotted by position in a 800-kb window versus association with mJSW (−log10 P) for A. rs2862851 (TGFA locus) and B. rs12206662/rs10948155 (SUPT3H/RUNX2 locus). The purple dot highlights the most sig-nificant SNP in discovery analysis. Blue peaks indicate recombination rates. The SNPs surrounding the most significant SNP are color coded to reflect their LD with this SNP (from pairwise r2 values from the HapMap CEU). Genes, exons and the direction of transcription from the University of California at Santa Cruz genome browser are depicted. Plots were generated using Locus Zoom [9] .