Feline Lindhout

3 Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons 105 Supplementary Figure 3. Developmental proteome dynamics upon centriole loss A. Correlative matrix of biological replicas of control neurons or Centrinone-B (Cent-B) treated neu- rons used for proteome analysis. B. Correlative analysis of relative protein expression in control neurons at day 7 to day 3 and day 1. Specific stem cell markers (blue), neuron markers (yellow), and axon markers (red) are highlighted. C. Correlative analysis of relative protein expression in Centrinone-B treated neurons at day 7 to day 3 and day 1. Specific stem cell markers (blue), neuron markers (yellow), and axon markers (red) are highlighted. D. Relative protein expression over time for stem cell proteins, neuron proteins, and axon proteins. E. Quantification of the total phalloidin intensity in a fan-like growth cone at day 5 and day 9. Data information: Data represent mean ± SEM.