Anne-Marie Koop

142 Supplemental figure 4. Regulators of metabolism. Meta-regression of mitochondrial content with degree of RV pressure load (A). PGC1� gene expression(B) and its relation with duration of pressure load shown by meta-regression in a bubble plot (C). Forrest plot of PGC1� protein expression (D). Forrest plot of PPAR� gene expression (E). Data are presented as Hedges’ g. Combined Hedges’ g are presented as squares: grey representing Hedges’ g of a specific model, black representing Hedges’ g of all included studies. Bars represent 95% confidence interval. Bubble size represents relative study precision, calculation based on standard deviation. Black line represents regression line, grey lines represents 95% confidence interval. CO = cardiac output, CI = cardiac index, TAPSE = tricuspid annular plane systolic movement, RVEF = RV ejection fraction, � = decreased, “=” = not statistically significant affected. 95% CI = 95% confidence interval, n = number of included animals, i 2 = level of heterogeneity. * = significantly (p < 0.05) increased compared to SuHx-model.