Anne-Marie Koop

1 23 66. Drake JI, Bogaard HJ, Mizuno S, Clifton B, Xie B, Gao Y, Dumur CI, Fawcett P, Voelkel NF, Natarajan R. Molecular signature of a right heart failure program in chronic severe pulmonary hypertension. Am J Respir Cell Mol B iol 2011;45:1239–1247. 67. Bartelds B, Knoester H, Smid GB, Takens J, Visser GH, Penninga L, Leij FR van der, Beaufort-Krol GC, Zijlstra WG, Heymans HS, Kuipers JR. Perinatal changes in myocardial metabolism in lambs. Circulation 2000;102:926–931. 68. Greiner EF, Guppy M, Brand K. Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. J Biol Chem 1994;269:31484–31490. 69. Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang Y-H, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Kenneth Weir E, Rehman J, Archer SL. Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res S.L. Archer, Department of Medicine, Section of Cardiology, Chicago, IL 60637, United States; 2012;110:1484–1497. 70. Allard MF, Schonekess BO, Henning SL, English DR, Lopaschuk GD. Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts. Am J Physiol - Hear Circ Physiol 1994;267. 71. Lopaschuk GD. Metabolic Modulators in Heart Disease – Past, Present and Future. Can J Cardiol Canadian Cardiovascular Society; 2017;33:838–849. 72. Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer SL. FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl) L. Piao, Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA.; 2013;91:333–346. 73. Liu A, Philip J, Vinnakota KC, Bergh F Van den, Tabima DM, Hacker T, Beard DA, Chesler NC. Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension. Physiol Rep 2017;5:1–12. 74. Fang Y-H, Piao L, Hong Z, Toth PT, Marsboom G, Bache-Wiig P, Rehman J, Archer SL. Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: Exploiting Randle’s cycle. J Mol Med S.L. Archer, Medicine/Cardiology, University of Chicago, Chicago, IL 60637, United States; 2012;90:31–43. 75. Rumsey WL, Abbott B, Bertelsen D, Mallamaci M, Hagan K, Nelson D, Erecinska M. Adaptation to hypoxia alters energy metabolism in rat heart. Am J Physiol - Hear Circ Physiol W.L. Rumsey, Zeneca Pharmaceuticals, Wilmington, DE 19850-5437, United States; 1999;276:H71–H80. 76. Nouette-Gaulain K, Malgat M, Rocher C, Savineau J-P, Marthan R, Mazat J-P, Sztark F. Time course of differential mitochondrial energy metabolism adaptation to chronic hypoxia in right and left ventricles. Cardiovasc Res F. Sztark, Laboratoire d’Anesthésiologie, E.A. Physiologie Mitochondriale, Universite Bordeaux 2, 33076 Bordordeaux, France; 2005;66:132–140. 77. Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J. Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med 2014;189:325–334.