Anne-Marie Koop

24 78. Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West JD, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty acid metabolic defects and right ventricular lipotoxicity in human pulmonary arterial hypertension. Circulation E.L. Brittain, Division of Cardiovascular Medicine, Vanderbilt University Medical School, Nashville, United States; 2016;133:1936–1944. 79. Zaffran S, Kelly RG, Meilhac SM, BuckinghamME, Brown NA. Right ventricular myocardium derives from the anterior heart field. Circ Res 2004;95:261–268. 80. Dyer LA, Kirby ML. The role of secondary heart field in cardiac development. Dev Biol Elsevier Inc.; 2009;336:137–144. 81. McFadden DG, Charité J, Richardson JA, Srivastava D, Firulli AB, Olson EN. A GATA- dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 2000;127:5331–5341. 82. Sun Y-M, Wang J, Qiu X-B, Yuan F, Li R-G, Xu Y-J, Qu X-K, Shi H-Y, Hou X-M, Huang R-T, Xue S, Yang Y-Q. A HAND2 loss-of-function mutation causes familial ventricular septal defect and pulmonary stenosis. G3 Genes, Genomes, Genet J. Wang, Department of Cardiology, Jing’an District Central Hospital, Shanghai, China; 2016;6:987–992. 83. Kolwicz SC, Tian R. Glucose metabolism and cardiac hypertrophy. Cardiovasc Res 2011;90:194–201. 84. Kelly RG, Brown NA, Buckingham ME. The Arterial Pole of the Mouse Heart Forms from Fgf10-Expressing Cells in Pharyngeal Mesoderm. Dev Cell 2001;1:435–440. 85. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cel l 2003;5:877–889. 86. Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 1997;16:154–160. 87. Dirkx E, Gladka MM, Philippen LE, Armand A, Kinet V, Leptidis S, Azzouzi H, Salic K, Bourajjaj M, Silva GJJ, Olieslagers S, Nagel R Van Der, Weger R De, Bitsch N, Kisters N, Seyen S, Morikawa Y, Chanoine C, Heymans S, Volders PGA, ThumT, Dimmeler S, Cserjesi P, Eschenhagen T, Paula A, Martins C, Windt LJ De, Azzouzi H El, Salic K, Bourajjaj M, et al. Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol Nature Publishing Group; 2013;15:1282–1293. 88. Wallace E, Morrell NW, Yang XD, Long L, Stevens H, Nilsen M, Loughlin L, Mair KM, Baker AH, MacLean MR. A sex-specific microRNA-96/5-hydroxytryptamine 1B axis influences development of pulmonary hypertension. Am J Respir Crit Care Med 2015; 191 :1432–1442. 89. Caruso P, Dempsie Y, Stevens HC, McDonald RA, Long L, Lu R, White K, Mair KM, McClure JD, Southwood M, Upton P, Xin M, Rooij E Van, Olson EN, Morrell NW, MacLean MR, Baker AH. A role for miR-145 in pulmonary arterial hypertension: Evidence from mouse models and patient samples. Circ Res 2012;111:290–300. 90. Gou D, Ramchandran R, Peng X, Yao L, Kang K, Sarkar J, Wang Z, Zhou G, Usha Raj J. Mir- 210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia. Am J Physiol - Lung Cell Mol Phys iol 2012;303:682–691. 91. Reddy S, Bernstein D. Molecular mechanisms of right ventricular failure. Circulation S. Reddy, Department of Pediatrics (Cardiology), Stanford Cardiovascular Institute, Stanford University, Lucile Packard Children’s Hospital, Palo Alto, United States; 2015;132:1734–1742.