Anne-Marie Koop

8 291 Combined overload No overload n Median (IQR) n Median (IQR) P-value‡ 28 5.0 (3.3-6.8) 16 4.0 (0.8-5.0) 0.190 28 129 (65-190) 16 48 (33-129) 0.015 * 28 12.6 (11.6-15.5) 16 11.8 (9.6-13.5) 0.296 28 0.380 (0.333-0.435) 16 0.395 (0.324-0.427) 0.201 28 342 (280-452) 16 284 (250-392) 0.050 28 26.8 (18.6-47.0) 16 23.2 (17.1-29.4) 0.128 28 1.33 (1.17-1.71) 16 1.17 (0.85-1.45) <0.001 *† 28 0.44 (0.00-2.30) 16 1.38 (0.00-7.24) 0.447 No residual loading Mild-moderate loading Severe loading 0 1 2 3 4 5 hsTnT NT-proBNP Gal-3 MR-proADM GDF-15 MPO ET-1 NP combined overload no residual overload mild-moderate overload severe overload mild-moderate severe overload p-value overload (n=13) (n=13) 5.0 (3.5-6.5) 5.0 (2.0-8.0) 0.604 160 (66-237) 126 (67-175) 0.027‡ 11.8 (11.6-14.7) 12.7 (11.3-15.7) 0.345 0.381 (0.316-0.460) 0.390 (0.348-0.434) 0.861 354 (276-492) 330 (276-397) 0.344 26.9 (19.5-53.9) 24.2 (14.2-41.5) 0.496 1.21 (1.14-1.54) 1.47 (1.21-1.82) 0.087 0.53 (0.00-6.45) 0.34 (0.00-1.70) 0.657 Figure 1 * no residual vs. severe overload † mild-moderate vs. severe overload ‡ no residual vs. mild-moderate overload