Anne-Marie Koop

292 A right ventricular hypertrophy versus biomarker levels hsTnT NT-proBNP Gal-3 MR-proADM GDF-15 MPO ET-1 NP Figure 2 (ng/l) (ng/l) (ng/ml) (mmol/l) (pg/ml) (ng/ml) (ng/ml) (pg/ml) NoRVH RVH NoRVH RVH NoRVH RVH NoRVH RVH NoRVH RVH NoRVH RVH NoRVH RVH NoRVH RVH B right ventricular dilatation versus biomarker levels hsTnT NT-proBNP Gal-3 MR-proADM GDF-15 MPO ET-1 NP (ng/l) (ng/l) (ng/ml) (mmol/l) (pg/ml) (ng/ml) (ng/ml) (pg/ml) NoRVdil. RVdil. NoRVdil. RVdil. NoRVdil. RVdil. NoRVdil. RVdil. NoRVdil. RVdil. NoRVdil. RVdil. NoRVdil. RVdil. NoRVdil. RVdil. 0 10 20 30 55 65 75 * 0 200 400 600 800 1000 1200 * 5 10 15 20 25 30 35 40 45 50 0.2 0.4 0.6 0.8 * 100 200 300 400 500 600 700 800 900 1000 9000 * 0 50 100 150 200 300 400 500 600 * 0 1 2 3 4 5 * 0 10 20 30 40 50 60 70 80 120 160 200 * 0 10 20 30 50 55 60 65 0 200 400 600 800 1000 1200 0 10 20 30 40 50 0.2 0.4 0.6 0.8 0 500 1000 2500 3500 4500 5500 6500 0 50 100 150 200 500 0 1 2 3 4 5 0 50 100 100 200 C right ventricular function determined by eyeballing versus biomarker levels hsTnT NT-proBNP Gal-3 MR-proADM GDF-15 MPO ET-1 NP (ng/l) (ng/l) (ng/ml) (mmol/l) (pg/ml) (ng/ml) (ng/ml) (pg/ml) Good Mod Bad Good Mod Bad Good Mod Bad Good Mod Bad Good Mod Bad Good Mod Bad Good Mod Bad Good Mod Bad 0 5 10 15 20 20 70 0 200 400 600 800 1000 1200 0 20 40 60 0.2 0.4 0.6 0.8 0 500 1000 1500 3000 6000 0 50 100 150 200 250 400 500 0 1 2 3 4 5 0 20 40 60 100 200 Figure 2. Relation between the plasma levels of the eight biomarkers and right ventricular hypertrophy ( A ), right ventricular dilatation ( B ) and subjective assessment of right ventricular function ( C ). NT-proBNP: N-Terminal pro-B-Type natriuretic peptide; MR-proADM: midregional proadrenomedullin; Gal-3: galectin-3; GDF-15: growth differentiation factor 15; MPO: myeloperoxidase; ET-1: endothelin-1; hsTnT: high sensitive Troponin T; NP: neprilysin; RVH: right ventricular hypertrophy; RV dil.: right ventricular dilatation; mod: moderate.