Anne-Marie Koop

2 35 PAB consistently induced RV dilatation and tricuspid insufficiency, but no differences were found between PAB- and PAB+CF ( table 1 ). Table 1. Additional heartcatheterization and echocardiographic data in CON, PAB- and PAB+CF. CON PAB- PAB+CF Number of rats 7 4 5 Weights Bodyweight at termination (g) 488±23 431±28* 456±21* RV free wall weight (mg) 272±18 624±47* 582±41* LV+IVS weight (mg) 883±48 846±92 823±54 Heartcath parameters HR (/min) 308±5 258±24 264±15 dP/dtmax corr 49.8±2.2 32.3±3.7* 32.6±1.7* dP/dtmin corr (*-1) 47.7±1.8 32.7±2.8* 23.9±4.0* Tau (ms) 17.6±0.5 27.3±3.9* 23.1±2.5 Tau/cyclelength (ms/s) 90±2 114±9* 100±8 Echocardiographic parameters 5wk Tricuspid insufficiency (present) 0% 100%* 100%* Pericardial effusion (present) 0% 0% 40%*† RVEDD (mm) 3.0±0.2 5.3±0.4* 6.0±0.1* PAB gradient (mmHg) 4±1 74±5* 64±9* RA diameter (mm) 3.5±0.1 5.2±0.3* 7.2±1.0* TAPSE (mm) 2.9±0.1 1.7±0.2* 1.3±0.2*† HR (/min) 368±8 315±18 279±20* SV (uL) 295±13 205±20* 153±17*† Echocardiographic parameters endpoint Tricuspid insufficiency (present) 0% 100%* 100%* Pericardial effusion (present) 0% 0% 60%*† RVEDD (mm) 4.5±0.1 6.2±0.2* 6.5±0.5* PAB gradient (mmHg) 3±1 72±11* 62±10* RA diameter (mm) 4.5±0.1 6.0±0.1* 7.7±0.6*† TAPSE (mm) 3.4±0.2 2.0±0.2* 1.2±0.1*† HR (/min) 368±6 304±11* 301±13* SV (uL) 426±30 271±24* 152±21*† LV= left ventricle, IVS= interventricular septum, HR= heart rate, dP/dt max corr= dP/dt max normalized for RV peak pressure, dP/dt min corr= dP/dt min normalized for RV end systolic pressure, RVEDD= right ventricular enddiastolic volume, PAB= pulmonary artery banding, RA= right atrium, TAPSE= tricuspid annular plane systolic excursion, SV= stroke volume. Values are mean ± SEM. *= p<0.05 vs. CON, † vs. PAB-