Anne-Marie Koop

48 15. Hessel MHM, Steendijk P, Adel B Den, Schutte CI, Laarse A Van Der. Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat. Am J Physiol - Hear Circ Physiol 2006;291:2424–2430. 16. Borgdorff M a J, Bartelds B, Dickinson MG, Boersma B, Weij M, Zandvoort A, Silljé HHW, Steendijk P, Vroomen M De, Berger RMF. Sildenafil enhances systolic adaptation, but does not prevent diastolic dysfunction, in the pressure-loaded right ventricle. Eur J Heart Fail 2012;14:1067–1074. 17. Schäfer S, Ellinghaus P, Janssen W, Kramer F, Lustig K, Milting H, Kast R, Klein M. Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right- ventricular remodelling. Cardiovasc Res 2009;82:30–39. 18. Borgdorff MA, Bartelds B, Dickinson MG, Steendijk P, Berger RMF. A cornerstone of heart failure treatment is not effective in experimental right ventricular failure. Int J Cardiol Elsevier Ireland Ltd; 2013;169:183–189. 19. Lin K, Kools H, Groot PJ de, Gavai AK, Basnet RK, Cheng F, Wu J, Wang X, Lommen A, Hooiveld GJEJ, Bonnema G, Visser RGF, Muller MR, Leunissen JAM. MADMAX – Management and analysis database for multiple ~omics experiments. J Integr Bioinform 2011;8:160. 20. Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Prot oc 2009;4:44–57. 21. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005;102:15545–15550. 22. Toischer K, Rokita AG, Unsöld B, Zhu W, Kararigas G, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preu L, Gupta SN, Schmidt K, Lehnart SE, Krüger M, Linke WA, Backs J, Regitz-Zagrosek V, Schäfer K, Field LJ, Maier LS, Hasenfuss G. Differential cardiac remodeling in preload versus afterload. Circulation 2010;122:993–1003. 23. Vaidya A, Kawut SM. Relax or contract: What’s right? Circulation 2013;128:1999–2001. 24. Rain S, Handoko ML, Trip P, Gan CT-J, Westerhof N, Stienen GJ, Paulus WJ, Ottenheijm CAC, Marcus JT, Dorfmüller P, Guignabert C, Humbert M, Macdonald P, Remedios C Dos, Postmus PE, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, Velden J Van Der, Man FS De. Right ventricular diastolic impairment in patients with pulmonary arterial hypertension. Circulation F.S. De Man, Department of Pulmonology, VU University Medical Center, Institute for Cardiovascular Research, 1081 HV Amsterdam, Netherlands; 2013;128:2016–2025. 25. Borgdorff MA, Bartelds B, Dickinson MG, Wiechen MPH van, Steendijk P, Vroomen M de, Berger RMF. Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload. AJP Hear Circ Physiol 2014;307:H361–H369. 26. Leeuwenburgh BPJ, Helbing WA, Steendijk P, Schoof PH, Baan JAN. Biventricular systolic function in young lambs subject to chronic systemic right ventricular pressure overload. Am J Physiol - Hear Circ Phy siol 2001;281:2697–2704. 27. Correia-Pinto J, Henriques-CoelhoT, Roncon-Albuquerque R, Leite-MoreiraAF. Differential right and left ventricular diastolic tolerance to acute afterload and NCX gene expression in