Anne-Marie Koop

2 59 SUPPLEMENTAL TABLES Supplemental table 1. Heartcatherization and echocardiographic data in PAB- and PAB (11w). PAB- PAB (11w) p-value Number of rats 4 3 Heartcath parameters HR (/min) 258±24 272±6 0.65 dP/dtmax corr 32.3±3.7 32.7±2.0 0.94 dP/dtmin corr (*-1) 32.7±2.8 32.1±3.7 0.89 Tau (ms) 27.3±3.9 25.4±0.7 0.70 Tau/cyclelength (ms/s) 114±9 115±4 0.91 Echocardiographic parameters 5wk Tricuspid insufficiency (%) 100% 100% 1.00 Pericardial effusion (%) 0% 0% 1.00 RVEDD (mm) 5.3±0.4 5.8±0.3 0.36 PAB gradient (mmHg) 74±5 63±4 0.17 RA diameter (mm) 5.2±0.3 3.5±0.4 0.19 TAPSE (mm) 1.7±0.2 1.9±0.4 0.52 HR (/min) 315±18 329±9 0.56 SV (uL) 205±20 233±6 0.29 Echocardiographic parameters endpoint Tricuspid insufficiency (%) 100% 100% 1.00 Pericardial effusion (%) 0% 0% 1.00 RVEDD (mm) 6.2±0.2 7.0±0.4 0.10 PAB gradient (mmHg) 72±11 113±12 0.06 RA diameter (mm) 6.0±0.1 6.5±0.3 0.13 TAPSE (mm) 2.0±0.2 2.0±0.1 0.96 HR (/min) 304±11 328±14 0.23 SV (uL) 271±24 292±33 0.63 HR= heart rate, dP/dt max corr= dP/dt max normalized for RV peak pressure, dP/dt min corr= dP/dt min normalized for RV end systolic pressure, RVEDD= right ventricular enddiastolic volume, PAB= pulmonary artery banding, RA= right atrium, TAPSE= tricuspid annular plane systolic excursion, SV= stroke volume. Values are mean ± SEM. Significance indicated by p-values from t-test PAB- vs. PAB(11w). Supplemental table 2. Genes up- or down regulated vs. CON in both PAB- and PAB+CF. Due to excessive length not added to this version of the manuscript.