Anne-Marie Koop

60 Supplemental table 3. Gene Sets specifically downregulated in PAB+CF CATEGORY GENE SET Glycolysis and glyconeogenesis REACT_GLUCOSE METABOLISM Metabolism miscellaneous REACT_PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE Activation and regulation REACT_PKB-MEDIATED EVENTS Activation and regulation REACT_MTOR SIGNALLING Glycolysis and glyconeogenesis REACT_GLUCONEOGENESIS Growth, proliferation and cellcyle WIP_RN_NUCLEAR_RECEPTORS Miscellaneous KEGG_05016_HUNTINGTON’S DISEASE Glycolysis and glyconeogenesis WIP_RN_GLYCOLYSIS_AND_GLUCONEOGENESIS Miscellaneous REACT_OLFACTORY SIGNALING PATHWAY Metabolism miscellaneous WIP_RN_TRYPTOPHAN_METABOLISM Growth, proliferation and cellcyle REACT_TRNA AMINOACYLATION Glycolysis and glyconeogenesis WIP_RN_GLYCOGEN_METABOLISM Metabolism miscellaneous KEGG_00380_TRYPTOPHAN METABOLISM Contraction and activation KEGG_04260_CARDIAC MUSCLE CONTRACTION Metabolism miscellaneous KEGG_00330_ARGININE AND PROLINE METABOLISM Development heart and muscle KEGG_05412_ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY (ARVC) Glycolysis and glyconeogenesis REACT_METABOLISM OF CARBOHYDRATES Miscellaneous KEGG_04910_INSULIN SIGNALING PATHWAY Miscellaneous WIP_RN_HYPOTHETICAL_NETWORK_FOR_DRUG_ADDICTION Activation and regulation REACT_CALMODULIN INDUCED EVENTS Activation and regulation REACT_PLC-GAMMA1 SIGNALLING Miscellaneous REACT_CAM PATHWAY Metabolism miscellaneous KEGG_00592_ALPHA-LINOLENIC ACID METABOLISM Metabolism miscellaneous KEGG_00230_PURINE METABOLISM Metabolism miscellaneous NCI_RETINOIC_ACID_PATHWAY Miscellaneous WIP_RN_MONOAMINE_GPCRS Glycolysis and glyconeogenesis KEGG_00051_FRUCTOSE AND MANNOSE METABOLISM Miscellaneous BIOC_INSULINPATHWAY Glycolysis and glyconeogenesis KEGG_00010_GLYCOLYSIS / GLUCONEOGENESIS Metabolism miscellaneous REACT_PEROXISOMAL LIPID METABOLISM Activation and regulation NCI_MAPKTRKPATHWAY SIZE= number of genes in respective GSEA set, NES= normalized enrichment score (analogous to fold change), NOM= nominal, FDR= false discovery rate.