Anne-Marie Koop

7 C O N T E N T CHAPTER 1 – Introduction. CHAPTER 2 – Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction. Journal of Molecular and Cellular Cardiology. 2015; 79:244-253. CHAPTER 3 – Metabolic remodelling in the pressure loaded right ventricle: shifts in glucose and fatty acid metabolism - a systematic review and meta-analysis. Journal of American Heart Association. 2019; 8. CHAPTER 4 – Right ventricular pressure overload alters cardiac lipid composition. International Journal of Cardiology. 2019; 287:96-105. CHAPTER 5 – Quantification of Biventricular Function and Morphology by Cardiac Magnetic Resonance Imaging in Mice with Pulmonary Artery Banding. Journal of Visualized Experiments. 2020. CHAPTER 6 – Increased miR-199b expression contributes to right and left ventricular remodelling in a mouse model of right ventricular pressure overload. Under revision. CHAPTER 7 – The adult heart requires baseline expression of the transcription factor Hand2 to withstand RV pressure overload. Under revision. CHAPTER 8 – Multi-biomarker assessment in children with congenital heart disease and various types of increased right ventricular load. In preparation. CHAPTER 9 – General discussion. APPENDICES Dutch summary About the author Acknowledgements 9 27 63 155 199 225 251 281 307 323 324 329 331