Anne-Marie Koop

70 Figure 1. Flow chart systematic study selection and inclusion meta-analysis. From three selected publications, three study groups were excluded (Balestra 2015, MCT30 28 ; Rumsey 1999, 1 day 29 ; and Zhang 2014, 2 weeks 30 ), since pressure load and hypertrophy did not increase significantly or was not reported. All other groups had at least increased RVSP ( suppl. figure 1a ), RV weight, Fulton index ( suppl. figure 1b ) or RV/BW ratio.