Anne-Marie Koop

84 Effect of interventions on metabolism in the pressure loaded RV Twenty studies described the effect of an intervention on metabolic parameter(s). Overall, these intervention studies were aiming to decrease glycolysis by the increase of glucose oxidation. This could be established by re-coupling of glycolysis with glucose oxidation, by e.g. DCA or DON, or indirectly by inhibition of fatty acid metabolism, by e.g. TMZ or RAN. Seven studies, included metabolic variables which were included in meta-analyses above. 15-21 Of these metabolic variables, effect sizes derived from certain metabolic variable of intervention group treated with metabolic therapy compared to those of intervention group without treatment, are shown in supplementaltable5 .TheeffectofdichloroacetateonPDHactivitywasstudiedinthree studies showing a significant increase a FHR model 16 , with contrary results regarding twoMCT-models 15,17 . The effects of a therapeutic interventions on all other 21 reported variables were studied incidentally, precluding data synthesis and conclusions.