Anne-Marie Koop

CHAPTER 1 – Introduction 9
CHAPTER 2 – Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction 27
CHAPTER 3 – Metabolic remodelling in the pressure loaded right ventricle: shifts in glucose and fatty acid metabolism - a systematic review and meta-analysis 63
CHAPTER 4 – Right ventricular pressure overload alters cardiac lipid composition 155
CHAPTER 5 – Quantification of Biventricular Function and Morphology by Cardiac Magnetic Resonance Imaging in Mice with Pulmonary Artery Banding 199
CHAPTER 6 – Increased miR-199b expression contributes to right and left ventricular remodelling in a mouse model of right ventricular pressure overload 225
CHAPTER 7 – The adult heart requires baseline expression of the transcription factor Hand2 to withstand RV pressure overload 251
CHAPTER 8 – Multi-biomarker assessment in children with congenital heart disease and various types of increased right ventricular load 281
CHAPTER 9 – General discussion 307
Dutch summary 324
About the author 329
Acknowledgements 331

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