Sara van den Berg

126 Chapter 5 REFERENCES 1. Cannon MJ, Schmid DS, Hyde TB. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol. 2010;20(4):202-13. 2. Sissons JG, Wills MR. How understanding immunology contributes to managing CMV disease in immunosuppressed patients: now and in future. Medical microbiology and immunology. 2015;204(3):307-16. 3. Holtappels R, Pahl-Seibert MF, Thomas D, Reddehase MJ. Enrichment of immediate-early 1 (m123/ pp89) peptide-specific CD8 T-cells in a pulmonary CD62L(lo) memory-effector cell pool during latent murine cytomegalovirus infection of the lungs. J Virol. 2000;74(24):11495-503. 4. Karrer U, Sierro S, Wagner M, Oxenius A, Hengel H, Koszinowski UH, et al. Memory inflation: continuous accumulation of antiviral CD8+ T-cells over time. J Immunol. 2003;170(4):2022-9. 5. O’Hara GA, Welten SP, Klenerman P, Arens R. Memory T-cell inflation: understanding cause and effect. Trends Immunol. 2012;33(2):84-90. 6. Khan N, Hislop A, Gudgeon N, Cobbold M, Khanna R, Nayak L, et al. Herpesvirus-specific CD8 T-cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J Immunol. 2004;173(12):7481-9. 7. Sylwester AW, Mitchell BL, Edgar JB, Taormina C, Pelte C, Ruchti F, et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T-cells dominate the memory compartments of exposed subjects. J Exp Med. 2005;202(5):673-85. 8. Komatsu H, Sierro S, Cuero V, Klenerman P. Population analysis of antiviral T-cell responses using MHC class I-peptide tetramers. Clin Exp Immunol. 2003;134(1):9-12. 9. Vescovini R, Biasini C, Fagnoni FF, Telera AR, Zanlari L, Pedrazzoni M, et al. Massive load of functional effector CD4+ and CD8+ T-cells against cytomegalovirus in very old subjects. J Immunol. 2007;179(6):4283-91. 10. Remmerswaal EB, Havenith SH, Idu MM, van Leeuwen EM, van Donselaar KA, ten BA, et al. Human virus-specific effector-type T-cells accumulate in blood but not in lymph nodes. Blood. 2012;119(7):1702-12. 11. Griffiths SJ, Riddell NE, Masters J, Libri V, Henson SM, Wertheimer A, et al. Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T-cells that re-express CD45RA. J Immunol. 2013;190(11):5363-72. 12. Engstrand M, Lidehall AK, Totterman TH, Herrman B, Eriksson BM, Korsgren O. Cellular responses to cytomegalovirus in immunosuppressed patients: circulating CD8+ T-cells recognizing CMVpp65 are present but display functional impairment. Clin Exp Immunol. 2003;132(1):96-104. 13. Leitenberg D, Boutin Y, Lu DD, Bottomly K. Biochemical association of CD45 with the T-cell receptor complex: regulation by CD45 isoform and during T-cell activation. Immunity. 1999;10(6):701-11. 14. Derhovanessian E, Maier AB, Hahnel K, Beck R, de Craen AJ, Slagboom EP, et al. Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. J Gen Virol. 2011;92(Pt 12):2746-56. 15. Kuijpers TW, Vossen MT, Gent MR, Davin JC, Roos MT, Wertheim-van Dillen PM, et al. Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV. J Immunol. 2003;170(8):4342-8. 16. Chen G, Shankar P, Lange C, Valdez H, Skolnik PR, Wu L, et al. CD8 T-cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection. Blood. 2001;98(1):156-64.