Sara van den Berg

151 6 T-cell dynamics in CMV Figure 3. Dynamics of CD4 + and CD8 + T-cells in CMV- and CMV+ individuals. A. Graphical representation of the study design for the deuterated water labelling protocol. B. Deuterium labelling enrichment (%DNA labelled) of different T-cell subpopulations in CMV- and CMV+ individuals. Label enrichment was scaled between 0 and 100% by normalizing for the estimated maximum enrichment of granulocytes (see Materials and methods ). Lines go through the mean of duplicate measurements. C. Summary of estimated production rates of T TN , T CM , and T EM/EMRA CD4 + and CD8 + T-cells in CMV- (blue symbols) and CMV+ (red symbols) individuals. All estimates