Sara van den Berg

18 Chapter 1 REFERENCES 1. Boots, A.M., et al., The influence of ageing on the development and management of rheumatoid arthritis. Nat Rev Rheumatol, 2013. 9(10): p. 604-13. 2. Muller, L., S. Di Benedetto, and G. Pawelec, The Immune System and Its Dysregulation with Aging. Subcell Biochem, 2019. 91: p. 21-43. 3. Derhovanessian, E., et al., Immunity, ageing and cancer. Immun Ageing, 2008. 5: p. 11. 4. Fleming, D.M. and A.J. Elliot, The impact of influenza on the health and health care utilisation of elderly people. Vaccine, 2005. 23 Suppl 1: p. S1-9. 5. Bodey, B., et al., Involution of the mammalian thymus, one of the leading regulators of aging. In Vivo, 1997. 11(5): p. 421-40. 6. Wertheimer, A.M., et al., Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T-cell subsets in humans. J Immunol, 2014. 192(5): p. 2143-55. 7. Arnold, C.R., et al., Gain and loss of T-cell subsets in old age--age-related reshaping of the T-cell repertoire. J Clin Immunol, 2011. 31(2): p. 137-46. 8. Pangrazzi, L. and B. Weinberger, T-cells, aging and senescence. Exp Gerontol, 2020. 134: p. 110887. 9. Kared, H., et al., CD57 in human natural killer cells and T-lymphocytes. Cancer Immunol Immunother, 2016. 65(4): p. 441-52. 10. Qi, Q., et al., Diversity and clonal selection in the human T-cell repertoire. Proc Natl Acad Sci U S A, 2014. 111(36): p. 13139-44. 11. Yoshida, K., et al., Aging-related changes in human T-cell repertoire over 20years delineated by deep sequencing of peripheral T-cell receptors. Exp Gerontol, 2017. 96: p. 29-37. 12. Nikolich-Zugich, J., M.K. Slifka, and I. Messaoudi, The many important facets of T-cell repertoire diversity. Nat Rev Immunol, 2004. 4(2): p. 123-32. 13. Olsson, J., et al., Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev, 2000. 121(1-3): p. 187-201. 14. Wikby, A., et al., Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol, 2002. 37(2-3): p. 445-53. 15. Stempel, M., B. Chan, and M.M. Brinkmann, Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway. Med Microbiol Immunol, 2019. 208(3-4): p. 495-512. 16. Wikby, A., et al., The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age. Biogerontology, 2008. 9(5): p. 299- 308. 17. Gkrania-Klotsas, E., et al., Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort. J Infect Dis, 2012. 206(12): p. 1897-903. 18. Mathei, C., et al., No relation between CMV infection and mortality in the oldest old: results from the Belfrail study. Age Ageing, 2015. 44(1): p. 130-5. 19. van Boven, M., et al., Infectious reactivation of cytomegalovirus explaining age- and sex-specific patterns of seroprevalence. PLoS Comput Biol, 2017. 13(9): p. e1005719. 20. Huang, Y., et al., Cytomegalovirus Shedding in Healthy Seropositive Female College Students: A 6-Month Longitudinal Study. J Infect Dis, 2018. 217(7): p. 1069-1073.

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