Sara van den Berg

181 7 Duration of CMV infection average (range 25-30 years). All individuals were analyzed for the presence of CMV-specific antibodies. At endpoint, 58% of the participants (n=155) were CMV-seropositive ( Table 1 and Supplementary Figure 1 ). No significant differences in age, educational level and sex were observed between CMV-seronegative (CMV-) and CMV-seropositive (CMV+) individuals ( Table 1 ). Follow-up time was similar for CMV- and CMV+ participants. Figure 1. Overview of the CMV antibody levels of all participants during time. A. Study design. Participants donat- ed blood 6 times in ~27 years. In 2016-2017, an extra sample was taken for extensive phenotyping of leukocytes subsets. B. CMV antibody levels were measured every 5-years and presented per age category at endpoint sep- arately for men and woman. Green lines show the antibody trajectories of CMV- participants, purple lines those of LT CMV+ participants and the bold blue lines those the participants that seroconverted during follow-up (ST CMV+ participants). Dotted horizontal line shows the cutoff value for seropositivity.