Sara van den Berg

1 19 General introduction 21. Stowe, R.P., et al., Chronic herpesvirus reactivation occurs in aging. Exp Gerontol, 2007. 42(6): p. 563-70. 22. Furui, Y., et al., Cytomegalovirus (CMV) seroprevalence in Japanese blood donors and high detection frequency of CMV DNA in elderly donors. Transfusion, 2013. 53(10): p. 2190-7. 23. Sylwester, A.W., et al., Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T-cells dominate the memory compartments of exposed subjects. J Exp Med, 2005. 202(5): p. 673-85. 24. Gordon, C.L., et al., Tissue reservoirs of antiviral T-cell immunity in persistent human CMV infection. J Exp Med, 2017. 214(3): p. 651-667. 25. Klenerman, P., The (gradual) rise of memory inflation. Immunol Rev, 2018. 283(1): p. 99-112. 26. Klenerman, P. and A. Oxenius, T-cell responses to cytomegalovirus. Nat Rev Immunol, 2016. 27. Bajwa, M., et al., CMV-specific T-cell responses at older ages: broad responses with a large central memory component may be key to long-term survival. J Infect Dis, 2017. 28. Khan, N., et al., Herpesvirus-specific CD8 T-cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J Immunol, 2004. 173(12): p. 7481-9. 29. Komatsu, H., et al., Population analysis of antiviral T-cell responses using MHC class I-peptide tetramers. Clin Exp Immunol, 2003. 134(1): p. 9-12. 30. Korndewal, M.J., et al., Cytomegalovirus infection in the Netherlands: seroprevalence, risk factors, and implications. J Clin Virol, 2015. 63: p. 53-8. 31. Parry, H.M., et al., Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years. Immun Ageing, 2016. 13: p. 1. 32. Alonso Arias, R., et al., Intensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system. J Virol, 2013. 87(8): p. 4486-95. 33. Turner, J.E., et al., Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Age (Dordr), 2014. 36(1): p. 287-97. 34. Wang, G.C., et al., Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study. Am J Epidemiol, 2010. 171(10): p. 1144-52. 35. Araujo Carvalho, A.C., et al., Association between human herpes virus seropositivity and frailty in the elderly: A systematic review and meta-analysis. Ageing Res Rev, 2018. 48: p. 145-152. 36. Vescovini, R., et al., Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J Immunol, 2010. 184(6): p. 3242-9. 37. Roberts, E.T., et al., Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up. Am J Epidemiol, 2010. 172(4): p. 363-71. 38. Weltevrede, M., et al., Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: A systematic review. Exp Gerontol, 2016. 39. Weinberger, B., et al., Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly. Hum Immunol, 2007. 68(2): p. 86-90. 40. Derhovanessian, E., et al., Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. J Gen Virol, 2011. 92(Pt 12): p. 2746-56. 41. Hassouneh, F., et al., Differential Effect of Cytomegalovirus Infection with Age on the Expression of CD57, CD300a, and CD161 on T-Cell Subpopulations. Front Immunol, 2017. 8: p. 649. 42. van der Heiden, M., et al., Differential effects of Cytomegalovirus carriage on the immune phenotype of middle-aged males and females. Sci Rep, 2016. 6: p. 26892.