Sara van den Berg

194 Chapter 7 REFERENCES 1. Dupont, L. and M.B. Reeves, Cytomegalovirus latency and reactivation: recent insights into an age old problem. Rev Med Virol, 2016. 26(2): p. 75-89. 2. Stowe, R.P., et al., Chronic herpesvirus reactivation occurs in aging. Exp Gerontol, 2007. 42(6): p. 563-70. 3. van Boven, M., et al., Infectious reactivation of cytomegalovirus explaining age- and sex-specific patterns of seroprevalence. PLoS Comput Biol, 2017. 13(9): p. e1005719. 4. Wertheimer, A.M., et al., Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T-cell Subsets in Humans. The Journal of Immunology, 2014. 192(5): p. 2143-2155. 5. Korndewal, M.J., et al., Cytomegalovirus infection in the Netherlands: seroprevalence, risk factors, and implications. J Clin Virol, 2015. 63: p. 53-8. 6. Stowe, R.P., et al., Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age. J Med Virol, 2012. 84(11): p. 1797-802. 7. Parry, H.M., et al., Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years. Immun Ageing, 2016. 13: p. 1. 8. Furui, Y., et al., Cytomegalovirus (CMV) seroprevalence in Japanese blood donors and high detection frequency of CMV DNA in elderly donors. Transfusion, 2013. 53(10): p. 2190-7. 9. Alonso Arias, R., et al., Intensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system. J Virol, 2013. 87(8): p. 4486-95. 10. Turner, J.E., et al., Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Age (Dordr), 2014. 36(1): p. 287-97. 11. Wang, G.C., et al., Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study. Am J Epidemiol, 2010. 171(10): p. 1144-52. 12. Araujo Carvalho, A.C., et al., Association between human herpes virus seropositivity and frailty in the elderly: A systematic review and meta-analysis. Ageing Res Rev, 2018. 48: p. 145-152. 13. Vescovini, R., et al., Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J Immunol, 2010. 184(6): p. 3242-9. 14. Gkrania-Klotsas, E., et al., Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort. J Infect Dis, 2012. 206(12): p. 1897-903. 15. Roberts, E.T., et al., Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up. Am J Epidemiol, 2010. 172(4): p. 363-71. 16. Kaczorowski, K.J., et al., Continuous immunotypes describe human immune variation and predict diverse responses. Proceedings of the National Academy of Sciences, 2017. 114(30): p. E6097-E6106. 17. Wertheimer, A.M., et al., Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T-cell subsets in humans. J Immunol, 2014. 192(5): p. 2143-55. 18. Weltevrede, M., et al., Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: A systematic review. Exp Gerontol, 2016. 19. Sylwester, A.W., et al., Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T-cells dominate the memory compartments of exposed subjects. J Exp Med, 2005. 202(5): p. 673-85. 20. van de Berg, P.J., et al., A fingerprint left by cytomegalovirus infection in the human T-cell compartment. J Clin Virol, 2008. 41(3): p. 213-7. 21. Klenerman, P. and A. Oxenius, T-cell responses to cytomegalovirus. Nat Rev Immunol, 2016.