Sara van den Berg

219 8 General discussion 20. den Elzen, W.P., et al., Cytomegalovirus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities. Vaccine, 2011. 29(29-30): p. 4869-74. 21. Enani, S., et al., Impact of ageing and a synbiotic on the immune response to seasonal influenza vaccination; a randomised controlled trial. Clin Nutr, 2017. 22. Derhovanessian, E., et al., Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly. J Immunol, 2014. 193(7): p. 3624-31. 23. Theeten, H., et al., Cellular Interferon Gamma and Granzyme B Responses to Cytomegalovirus-pp65 and Influenza N1 Are Positively Associated in Elderly. Viral Immunol, 2016. 29(3): p. 169-75. 24. Chanouzas, D., et al., Subclinical Reactivation of Cytomegalovirus Drives CD4+CD28null T-Cell Expansion and Impaired Immune Response to Pneumococcal Vaccination in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. J Infect Dis, 2019. 219(2): p. 234-244. 25. Miles, D.J., et al., Cytomegalovirus infection induces T-cell differentiation without impairing antigen- specific responses in Gambian infants. Immunology, 2008. 124(3): p. 388-400. 26. Pera, A., et al., CMV latent infection improves CD8+ T response to SEB due to expansion of polyfunctional CD57+ cells in young individuals. PLoS One, 2014. 9(2): p. e88538. 27. Derhovanessian, E., A. Larbi, and G. Pawelec, Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr Opin Immunol, 2009. 21(4): p. 440-5. 28. Pawelec, G.A., A. Caruso, C. Grubeck-Loebenstein, B. Solana, R. Wikby, A. , Human immunosenescence: is it infectious? Immunological Reviews, 2005. 205: p. 257–268. 29. Tu, W. and S. Rao, Mechanisms Underlying T-cell Immunosenescence: Aging and Cytomegalovirus Infection. Front Microbiol, 2016. 7: p. 2111. 30. Khan, N., et al., Herpesvirus-specific CD8 T-cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J Immunol, 2004. 173(12): p. 7481-9. 31. Selin, L.K., et al., Attrition of T-cell memory: selective loss of LCMV epitope-specific memory CD8 T-cells following infections with heterologous viruses. Immunity, 1999. 11(6): p. 733-42. 32. Welsh, R.M. and L.K. Selin, Attrition of memory CD8 T-cells. Nature, 2009. 459(7247): p. E3-4; discussion E4. 33. Gordon, C.L., et al., Tissue reservoirs of antiviral T-cell immunity in persistent human CMV infection. J Exp Med, 2017. 214(3): p. 651-667. 34. Remmerswaal, E.B., et al., Human virus-specific effector-type T-cells accumulate in blood but not in lymph nodes. Blood, 2012. 119(7): p. 1702-12. 35. Barnstorf, I., et al., Chronic virus infection compromises memory bystander T-cell function in an IL-6/STAT1-dependent manner. J Exp Med, 2019. 216(3): p. 571-586. 36. Bartlett, D.B., et al., The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. Aging Cell, 2012. 11(5): p. 912-5. 37. Marandu, T.F., et al., Mouse CMV infection delays antibody class switch upon an unrelated virus challenge. Exp Gerontol, 2014. 54: p. 101-8. 38. Frasca, D., et al., Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine. Vaccine, 2015. 33(12): p. 1433-9. 39. Frasca, D. and B.B. Blomberg, Aging, cytomegalovirus (CMV) and influenza vaccine responses. Human Vaccines and Immunotherapeutics, 2016. 12(3): p. 682-690. 40. Moss, P., ‘From immunosenescence to immune modulation’: a re-appraisal of the role of cytomegalovirus as major regulator of human immune function. Med Microbiol Immunol, 2019. 208(3-4): p. 271-280.

RkJQdWJsaXNoZXIy ODAyMDc0