Sara van den Berg

221 8 General discussion 60. Jackson, S.E., et al., Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T-cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV- Specific T-cells. Front Immunol, 2017. 8: p. 733. 61. Parry, H.M., et al., Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years. Immun Ageing, 2016. 13: p. 1. 62. Onyeagocha, C., et al., Latent cytomegalovirus infection exacerbates experimental colitis. Am J Pathol, 2009. 175(5): p. 2034-42. 63. Santos Rocha, C., et al., Subclinical cytomegalovirus infection associates with altered host immunity, gut microbiota and vaccine responses. J Virol, 2018. 64. Beura, L.K., et al., Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature, 2016. 532(7600): p. 512-6. 65. Rosshart, S.P., et al., Laboratory mice born to wild mice have natural microbiota and model human immune responses. Science, 2019. 365(6452). 66. Korndewal, M.J., et al., Cytomegalovirus infection in the Netherlands: seroprevalence, risk factors, and implications. J Clin Virol, 2015. 63: p. 53-8. 67. Gostic, K.M., et al., Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting. Science, 2016. 354(6313): p. 722-726. 68. Viboud, C. and S.L. Epstein, First flu is forever. Science, 2016. 354(6313): p. 706-707. 69. Wertheimer, A.M., et al., Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T-cell subsets in humans. J Immunol, 2014. 192(5): p. 2143-55. 70. Mortensen, L.H., et al., Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins. Epidemiol Infect, 2012. 140(5): p. 835-41. 71. Liu, J., et al., Promising Cytomegalovirus-Based Vaccine Vector Induces Robust CD8(+) T-Cell Response. Int J Mol Sci, 2019. 20(18).