Sara van den Berg

41 2 CMV on influenza vaccination Supplementary Figure 1. Effect of CMV infection on unadjusted influenza antibody titer and protection rate to pandemic influenza infection. Geometric mean and 95% CI of influenza antibody titers and the percentage protected (defined as a titer ≥ 40) are shown for CMV+ and CMV- individuals ( A, B ) and for CMV-seropositive individuals with low, medium and high anti-CMV IgG levels ( C, D ) before and after pandemic vaccination with H1N1pdm in 2009. Arrows (↓) indicate the moment of vaccination. Dotted horizontal line represents a protective influenza titer of 40 HAU. Significant differences are tested by T test for influenza antibody titers and by Fisher exact test between CMV-seropositive and CMV-seronegative individuals or anti-CMV IgG group high and low per separate time point.