Sara van den Berg

43 2 CMV on influenza vaccination Influenza antibody titer Protection Parameter B (beta) Standard Error Sig (P-value) B (beta) Standard Error Sig (P-value) (Intercept) 3.783 0.3168 0 -1.199 0.3872 0.002 Age group 2 (40-52 year) -0.629 0.2547 0.013 -0.59 0.3226 0.068 Age group 1 (30-40 year) -0.014 0.2596 0.958 -0.023 0.3358 0.946 Age group 0 (18-30 year) 0a . . 0a . . Sex male 0.161 0.1974 0.414 -0.074 0.247 0.765 Sex female 0a . . 0a . . Previous influenza vaccinations yes -0.583 0.3263 0.074 -0.607 0.4259 0.154 Previous influenza vaccinations sometimes -0.459 0.2442 0.06 -0.381 0.346 0.27 Previous influenza vaccinations no 0 a . . 0 a . . Seasonal 2009 vaccination before study yes 0.017 0.2758 0.952 0.803 0.3979 0.043 Seasonal 2009 vaccination before study no 0 a . . 0 a . . Seasonal 2009 vaccination during study yes -0.004 0.2612 0.989 -0.094 0.3367 0.779 Seasonal 2009 vaccination during study no 0 a . . 0 a . . CMV-serostatus positive -0.029 0.2395 0.903 0.189 0.3461 0.586 CMV-serostaus negative 0 a . . 0 a . . Timepoint 5 2.679 0.29 < 0.001 2.375 0.3555 < 0.001 Timepoint 4 3.286 0.2388 < 0.001 3.071 0.3557 < 0.001 Timepoint 3 4.344 0.2405 < 0.001 4.148 0.415 < 0.001 Timepoint 2 4.089 0.2684 < 0.001 3.466 0.3828 < 0.001 Timepoint 1 0 a . . 0 a . . CMV-serostatus positive * Timepoint 5 0.243 0.3385 0.473 0.63 0.4587 0.17 CMV-serostatus positive * Timepoint 4 0.155 0.2825 0.582 0.582 0.4633 0.209 CMV-serostatus positive * Timepoint 3 0.138 0.2892 0.632 0.613 0.6122 0.317 CMV-serostatus positive * Timepoint 2 0.122 0.3201 0.703 0.188 0.4869 0.7 CMV-serostatus positive * Timepoint 1 0 a . . 0 a . . CMV-serostatus negative * Timepoint 5 0 a . . 0 a . . CMV-serostatus negative * Timepoint 4 0 a . . 0 a . . CMV-serostatus negative * Timepoint 3 0 a . . 0 a . . CMV-serostatus negative * Timepoint 2 0 a . . 0 a . . CMV-serostatus negative * Timepoint 1 0 a . . 0 a . . Supplementary Table 2. Regression table effect CMV-serostatus on pandemic influenza vaccine response of H1N1pdm strain in the pandemic season. Bold: p value < 0.10 Bold and underlined: p value < 0.05. a reference category

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