Sara van den Berg

60 Chapter 3 Studies (reference article) Country Primary study design Design for research question Sample size Age (groups) Timeline Turner et al, 2014 UK RCT cohort 158 21 average Den Elzen et al , 2011 Netherlands RCT cohort 731 77-88 Derhovanessian et al , 2012 Belgium phase III trial cohort 54 19-81 Nielsen et al , 2015 UK cross sectional cross sectional 152 20-77 Furman et al , 2015 – study 1 USA cohort cohort 91 20-32 and >60 Furman et al , 2015 – study 2 USA cohort cohort 77 21-33 and >60 Furman et al , 2015 – study 3 USA cohort cohort 37 19-44 Haq et al , 2016 Canada case-control cohort 70 >65 McElhaney et al , 2015 Canada cohort cohort 119 >65