Sara van den Berg

TABLE OF CONTENT Chapter 1 General introduction and scope of this thesis 9 PART I: DOES CMV INFECTION HAMPER THE IMMUNE RESPONSE TO INFLUENZA? Chapter 2 Negative effect of age, but not of latent cytomegalovirus infection on the antibody response to a novel influenza vaccine strain in healthy adults 2018 Frontiers in Immunology doi: 10.3389/fimmu.2018.00082 23 Chapter 3 Effect of latent cytomegalovirus infection on the antibody response to influenza vaccination: a systematic review and meta-analysis 2019 Medical Microbiology and Immunology doi: 10.1007/s00430-019-00602-z 53 Chapter 4 Latent cytomegalovirus infection does not affect the immune response to influenza virus infection in older adults Manuscript in preparation 89 PART II: CMV-INDUCED CHANGES OF THE T-CELL POOL IN OLDER ADULTS Chapter 5 The hallmarks of CMV-specific CD8 + T-cell differentiation 2019 Medical Microbiology and Immunology doi: 10.1007/s00430-019-00608-7 117 Chapter 6 Quantification of T-cell dynamics during latent human cytomegalovirus infection Manuscript in preparation 137 Chapter 7 Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year long longitudinal study 2020 Clinical and Translational Immunology Accepted for publication 175 Chapter 8 General discussion 205 Appendix Nederlandse samenvatting Curriculum vitae List of publications Dankwoord 225 233 235 237