Sara van den Berg

78 Chapter 3 #4 ‘influenza vaccination’/exp 13,281 #3 ‘influenza vaccine’/exp 30,951 #2 ‘cytomegalovirus’/exp 34,775 #1 ‘cytomegalovirus infection’/exp 34,353 Supplementary Table 1. Literature search strategy for the effect of CMV infection on the immune response to influenza vaccination. Results represent the number of articles. Search was performed on 27 june 2017. Data extraction form per study Characteristics of studies (Summarized in Table 1) Primary study design Design for research question Original paper URL Conclusion/ summary Population (sample size and age) Exclusion criteria Setting (country etc) Timeline Influenza vaccine outcomes (Summarized in Table 2) Increase GMT (outcome 1) Response (outcome 2) Correlation (outcome 3) Antibodies (another way) Model (corrected) Cellular Conclusion articles (Summarized in Figure 3, and Supplementary table 3) Influenza virus strain(s) antibodies measured Reported effect of CMV Young study group Reported effect of CMV Old study group Statistical method Risk of bias and study quality of studies included for systematic assessment (summarized in Table 3) Study controls for Statistical method appropriate Selection (max 4*) Comparability (max 2*) Outcome (max 3*) Overall score (+/-) Influenza vaccination (summarized in Supplementary table 4) Type vaccine year and pandamic or seasonal Dose influenza virus strain(s) Booster Time and type of measurement of influenza and CMV antibodies (summarized in Supplementary table 5) Influenza antibody measurement CMV antibody measurement Time after vaccination Assay of measurement Vaccination history Assay of measurement Cut-off CMV- seropositive Borderline handling Supplementary Table 2. Data extraction form per study.