Milea Timbergen

142 Acknowledgements Martijn P.A. Starmans acknowledges funding from the research program STRaTeGy (project number 14929-14930), which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO). This work was partially carried out on the Dutch national e-infrastructure with the support of SURF Cooperative. Sources of funding for research This study was financed by the Stichting Coolsingel (reference number 567), a Dutch non- profit foundation. Competing Interests Wiro J. Niessen is founder, scientific lead and stock holder of Quantib BV. The other authors do not declare any conflicts of interest. 5