Milea Timbergen

150 Supplemental Table 1. Overview of the 411 features used in this study. GLCM and GLCMMS features were calculated in four different directions (0, 45, 90, 135 degrees) using 16 gray levels and pixel distances of 1 and 3. LBP features were calculated using the following three parameter combinations: 1 pixel radius and 8 neighbours, 2 pixel radius and 12 neighbours, and 3 pixel radius and 16 neighbours. Gabor features were calculated using three different frequencies (0.05, 0.2, 0.5) and four different angles (0, 45, 90, 135 degrees). LoG features were calculated using three different widths of the Gaussian (1, 5 and 10 pixels). Vessel features were calculated using the full mask, the edge, and the inner region. Local phase features were calculated on the monogenic phase, phase congruency and phase symmetry. Histogram (12 features): min max mean median std skewness kurtosis peak range energy quartile range entropy Shape (17 features): compactness (mean + std) radius (mean + std) roughness (mean + std) convexity (mean + std) circular variance (mean + std) principal axes ratio (mean + std) elliptic variance (mean + std) solidity (mean + std) volume GLCM (6*4*2=48 features): contrast dissimilarity homogeneity angular second moment (ASM) energy correlation GLCMMS (12*4*2=96 features): contrast (mean + std) dissimilarity (mean + std) homogeneity (mean + std) ASM (mean + std) energy (mean + std) correlation (mean + std) NGTDM (5 features): busyness coarseness complexity contrast strength Gabor (6*4*3=72 features): mean std min max skewness kurtosis GLSZM (16 features): GrayLevelNonUniformity GrayLevelNonUniformityNormalized GrayLevelVariance HighGrayLevelZoneEmphasis LargeAreaEmphasis LargeAreaHighGrayLevelEmphasis LargeAreaLowGrayLevelEmphasis LowGrayLevelZoneEmphasis SizeZoneNonUniformity SizeZoneNonUniformityNormalized SmallAreaEmphasis SmallAreaHighGrayLevelEmphasis SmallAreaLowGrayLevelEmphasis ZoneEntropy ZonePercentage ZoneVariance GLRM (16 features): GrayLevelNonUniformity GrayLevelNonUniformityNormalized GrayLevelVariance HighGrayLevelRunEmphasis LongRunEmphasis LongRunHighGrayLevelEmphasis LongRunLowGrayLevelEmphasis LowGrayLevelRunEmphasis RunEntropy RunLengthNonUniformity RunLengthNonUniformityNormalized RunPercentage RunVariance ShortRunEmphasis ShortRunHighGrayLevelEmphasis ShortRunLowGrayLevelEmphasis 5