Milea Timbergen

206 a Reason for exclusion n = 29 n = 1 paediatric cohort n = 14 no CTNNB1 mutation type data available n = 3 no full text available n = 1 conference abstract n = 6 no recurrence data described n = 1 no DTF as a main subject n = 3 review, no original article b Number of eligible studies for which IPD were not sought (give reasons) n=8 n = 8 overlapping databases (defined as using a cohort from the same institute(s)) c Number participants for whom no data were provided n = 385 patientsw • n = 270 corresponding authors not willing to participate • n = 115 unknown reasons, possible exclusion by the corresponding authors due to our inclusion criteria d Number of studies for which IPD were not provided n = 3 corresponding authors not willing to participate e Number participants excluded n = 350 Colombo et al. 23 (n = 179) Total excluded patients: n = 68 Total included patients: n = 111 n = 32 intra-abdominal DTF n = 29 other treatment than surgery alone n = 7 age <18 years Mussi et al. 41 (n=25) Total excluded patients: n = 8 Total included patients: n = 17 n = 1 other treatment than surgery alone n = 4 wait and see only n = 1 R2 resection n = 2 recurrent tumours van Broekhoven et al. 22 (n = 101) Total excluded patients: n = 54 Total included patients: n = 47 n = 40 adjuvant radiotherapy n = 4 other treatment than surgery alone n = 6 age <18 years n = 1 other mutation n = 3 intra-abdominal DTF Mullen et al. 20 (n = 115) Total excluded patients: n = 52 Total included patients: n = 63 n = 8 pre-/ post-operative radiotherapy n = 2 pre-/ post-operative photon therapy n = 13 intra-abdominal DTF n = 10 systemic treatment n = 2 second gross resection n = 1 other mutation n = 6 age <18 years n = 10 recurrent tumours Nishida et al. 42 (n = 11) Total excluded patients: n = 8 Total included patients: n = 3 n = 8 other treatment than surgery alone Salas et al. 49 (n = 89) Total excluded patients n = 50 Total included patients: n = 39 n = 1 other mutation n = 14 age <18 years n = 1 recurrence unknown n = 31 recurrent tumours n = 3 unknown tumour status Kim et al. 43 (n = 159) Total excluded patients: n = 110 Total included patients: n = 49 n = 20 other treatment than surgery alone n = 10 age <18 years n = 6 other mutation n = 15 intra-abdominal DTF n = 1 unknown tumour status n = 18 recurrent tumours n = 40 other diagnosis (Dupuytren’s contracture, plantar fibromatosis) 7