Milea Timbergen

213 Supplementary Table 6. Cox proportional hazards regression multivariable analysis for recurrence, categorized according to tumour size n = 136 Variable HR (95% CI) p-value Tumour size 0- 55 mm Sex 0.203 Female 1.00 (reference) - Male 1.81 (0.72-4.48) 0.203 Age 0.98 (0.96-1.01) 0.177 Mutation type 0.020 S45F 1.00 (reference) - T41A 0.32 (0.12-0.87) 0.026 S45P 0.07 (0.01-0.77) 0.030 WT 0.31 (0.11-0.92) 0.035 Tumour site 0.107 Trunk / back 1.00 (reference) - Head / neck 11 (1.44-86.91) 0.021 Extremity 1.64 (0.55-4.92) 0.375 EA NS 1.9 (0.53-6.89) 0.324 Tumour size b 4.37 (1.39-13.8) 0.012 n = 139 Tumour size >55 mm Sex 0.853 Female 1.00 (reference) Male 1.08 (0.50-2.33) 0.853 Age 0.99 (0.97-1.01) 0.390 Mutation type 0.294 S45F 1.00 (reference) T41A 1.46 (0.69-3.13) 0.326 S45P 0.76 (0.20-2.87) 0.687 WT 0.56 (0.18-1.73) 0.316 Tumour site 0.001 Trunk / back 1.00 (reference) Head / neck 0 (0) 0.982 Extremity 6.25 (2.43-16.07) <0.001 EA NS 2.06 (0.81-5.29) 0.132 Tumour size b 1.80 (0.77-4.20) 0.173 HR, hazard ratio; CI, confidence interval; WT, wild-type; EA NS, extra-abdominal not specified a Cohort was used as a stratification variable due to a violation of the proportional hazards assumption (p=0.019) b Used as a log transformed value 7