Milea Timbergen

255 Table 3 Results of the EORTC QLQ-C30 questionnaire (version 3.0) of patients and the general population Total mean (SD) patients British participating patients, n = 12 mean (SD) Dutch participating patients, n = 17 mean (SD) p-value Dutch general population, n = 170 mean (SD) British general population, n = 80 a mean (SD) Dyspnea 10.3 (23.7) 8.0 (15.1) 11.8 (28.7) 0.845 8.2 (19.1) 18.7 (11.8) Insomnia 31 (38.8) 55.6 (38.4) 13.7 (29.0) 0.004* 20.8 (25.1) 37.9 (39.6) Appetite loss 14.9 (26.1) 22.2 (21.7) 9.8 (28.3) 0.073 2.9 (11.9) 16.2 (24.8) Constipation a 16.7 (32.1) 21.2 (37.3) 13.7 (29.0) 0.781 4.7 (13.7) 14.6 (30.9) Diarrhoea 17.2 (30.4) 27.8 (39.8) 9.8 (19.6) 0.325 7.3 (17.9) 14.2 (45.2) Financial difficulties 11.5 (24.0) 22.2 (29.6) 3.9 (16.2) 0.059 5.7 (18.9) 23.3 (34.5) Nausea/vomiting 7.5 (17.6) 13.9 (24.4) 2.9 (8.8) 0.180 4.7 (13.7) 14.6 (28.8) Pain 33.9 (36.0) 58.3 (37.3) 16.7 (23.6) 0.004* 16.2 (21.9) 29.4 (40.3) Fatigue 31 (32.9) 49.1 (29.0) 18.3 (29.9) 0.004* 22.5 (22.4) 33.9 (32.2) Cognitive functioning 79.9 (30.3) 65.3 (32.1) 90.2 (25.0) 0.030* 91.7 (15.7) 76.7 (29.5) Emotional functioning 73.6 (32.4) 59.0 (33.6) 83.8 (28.2) 0.021* 84.3 (18.9) 67.3 (36.7) Social functioning 77.6 (29.6) 58.3 (33) 91.2 (17.8) 0.001* 94.2 (14.9) 75.4 (38.8) Physical functioning 75.2 (27.9) 67.8 (32.5) 80.3 (23.9) 0.394 92.5 (13.1) 80.2 (33.3) Role functioning 71.8 (32.8) 52.8 (40.1) 85.3 (17.6) 0.027* 91.8 (19.5) 76.5 (38.8) Global health status 68.7 (27.7) 56.9 (29.5) 77.0 (23.9) 0.043* 78.7 (18.2) 60.2 (34.6) Summary score 78.1 63.5 87.2 89.8 76.7 a data missing from 1 British patient; * statistically significant difference Mean scores with standard deviation (SD) are displayed for all scales of the EORTC QLQ-C30. The p-value represents the comparison of the scores of the British participating patients versus the scores of the Dutch participating patients. Two-sided p<0.05 was considered statistically significant. 9