Milea Timbergen

49 57 . Picariello L, Brandi ML, Formigli L, Orlandini SZ, Dolara P, Caderni G, et al. Apoptosis induced by sulindac sulfide in epithelial and mesenchymal cells from human abdominal neoplasms. Eur J Pharmacol. 1998;360(1):105-112. 58 . Halberg RB, Katzung DS, Hoff PD, Moser AR, Cole CE, Lubet RA, et al. Tumorigenesis in the multiple intestinal neoplasia mouse: Redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A. 2000;97(7):3461-3466. 59 . Martinico SCM, Jezzard S, Sturt NJH, Michils G, Tejpar S, Phillips RK, et al. Assessment of endostatin gene therapy for familial adenomatous polyposis-related desmoid tumors. Cancer Res. 2006;66(16):8233-8240. 60 . Poon R, Hong H, Wei X, Pan J, Alman BA. A high throughput screen identifies Nefopam as targeting cell proliferation in beta-catenin driven neoplastic and reactive fibroproliferative disorders. PLoS ONE. 2012;7(5):e37940. 61 . Ghanbari-Azarnier R, Sato S, Wei Q, Al-Jazrawe M, Alman BA. Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling. Neoplasia. 2013;15(7):712-719. 62 . Shang H, Braggio D, Lee YJ, Al Sannaa GA, Creighton CJ, Bolshakov S, et al. Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors. Cancer. 2015;121(22):4088-4096. 63 . Tjandra SS, Hsu C, Goh I, Gurung A, Poon R, Nadesan P, et al. IFN-β signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors. Cancer Res. 2007;67(15):7124-7131. 64 . Rosenberg L, Yoon CH, Sharma G, Bertagnolli MM, Cho NL. Sorafenib inhibits proliferation and invasion in desmoid-derived cells by targeting Ras/MEK/ERK and PI3K/Akt/mTOR pathways. Carcinogenesis. 2018;39(5):681-688. 65 . Locci P, Balducci C, Lilli C, Marinucci L, Becchetti E, Dolci C, et al. Desmoid and fibroma tumors differently respond to TGFβ1 stimulus and ECM macromolecule accumulation. Biomed Pharmacother. 2007;61(2-3):131-136. 66 . Amini Nik S, Ebrahim RP, Van Dam K, Cassiman JJ, Tejpar S. TGF-beta modulates beta-Catenin stability and signaling in mesenchymal proliferations. Exp Cell Res. 2007;313(13):2887-2895. 67 . Trang SH, Joyner DE, Damron TA, Aboulafia AJ, Lor Randall R. Potential for functional redundancy in EGF and TGFα signaling in desmoid cells: A cDNAmicroarray analysis. Growth Factors. 2010;28(1):10-23. 68 . Joyner DE, Trang SH, Damron TA, Aboulafia AJ, Cummings JE, Randall RL. Desmoid cell motility is induced in vitro by rhEGF. J Orthop Res. 2009;27(9):1258-1262. 69 . Serpell JW, Paddle-Ledinek JE, Johnson WR. Modification of growth of desmoid tumours in tissue culture by anti- oestrogenic substances: A preliminary report. Aust New Zealand J Surg. 1996;66(7):457-463. 70 . Stabellini G, Balducci C, Lilli C, Marinucci L, Becchetti E, Carinci F, et al. Toremifene decreases type I, type II and increases type III receptors in desmoid and fibroma and inhibits TGFbeta1 binding in desmoid fibroblasts. Biomed Pharmacother. 2008;62(7):436-442. 71 . Balducci C, Lilli C, Stabellini G, Marinucci L, Giustozzi G, Becchetti A, et al. Human desmoid fibroblasts: matrix metalloproteinases, their inhibitors and modulation by Toremifene. BMC Cancer. 2005;5:22. 72 . Locci P, Bellocchio S, Lilli C, Marinucci L, Cagini L, Baroni T, et al. Synthesis and secretion of transforming growth factor-β1 by human desmoid fibroblast cell line and its modulation by toremifene. J Interferon Cytokine Res. 2001;21(11):961-970. 73 . Signoroni S, Frattini M, Negri T, Pastore E, Tamborini E, Casieri P, et al. Cyclooxygenase-2 and platelet-derived growth factor receptors as potential targets in treating aggressive fibromatosis. Clin Cancer Res. 2007;13(17):5034-5040. 74 . Matono H, Tamiya S, Yokoyama R, Saito T, Iwamoto Y, Tsuneyoshi M, et al. Abnormalities of the Wnt/β-catenin signalling pathway induce tumour progression in sporadic desmoid tumours: Correlation between β-catenin widespread nuclear expression and VEGF overexpression. Histopathology. 2011;59(3):368-375. 2

RkJQdWJsaXNoZXIy ODAyMDc0