Milea Timbergen

54 Supplemental Materials 1 List of abbreviations used in this manuscript ADAM AKT APC BOC BMP CDON CK COX CSL CR CRC DFMO DFU Dhh DLL DVL DTF EGF ER ERE ERK FAP GAG GAS GIST GLI GPCR GSI GSK HES Hh HHIP Hsp IGF IFN Ihh IL Jag JAK KIF7 KIT LEF LRP MAML1 A disintegrin and metalloproteinase AKT8 virus oncogene cellular homolog Adenomatous polyposis coli Brother of CDON Bone morphogenetic protein Cell adhesion associated, oncogene regulated Casein kinase Cyclooxygenase CBF1/ Suppressor of hairless/Lag-1 Complete response Colorectal cancer Difluoromethylornithine Selective COX-2 blocker (5,5-dimethyl-3-(3- uorophenyl)4-(4-methylsulphonyl)phenyl- 2(5H)-furon one) Desert hedgehog Delta-Like Canonical Notch Ligand Dishevelled protein Desmoid-type fibromatosis Epidermal growth facto Estrogen receptors Estrogen response elements extracellular signal-regulated kinase Familial adenomatous polyposis Glycosaminoglycans Growth arrest specific Gastro-intestinal stromal tumours Glioma-associated oncogene G-protein coupled receptor Gamma-Secretase Inhibitors Glycogen synthase kinase Hairy enhancer of split /HES Family BHLH Transcription Factor Hedgehog Hedgehog interacting protein Heat shock proteins Insulin growth factor Interferon Indian hedgehog Interleukins Jagged Janus-activated kinase Kinesin family protein v-KIT Hardy-Zuckerman 4 Feline Sarcoma viral oncogene homolog/ KIT oncogene Lymphoid enhancer factor Lipoprotein receptor-related protein Mastermind-like 1 MAPK MEK MET MMP mTOR NECD NF NICD NPRR NR NTMD NSAID ORR OS PAR PCC PD PDK PDGF(R) ɑ/ß PFS PH PI3 PI3K PIP3 PR PTCH1 PTEN RTK SD Shh SMAD SMO STAT SUFU TCF TGF-ß TKI TS TTF TTP VEGF WT WISP Wnt Mitogen-activated protein kinase MAPK/Erk kinase Hepatocyte growth factor receptor Matrix Metalloproteinase Mechanistic Target Of Rapamycin Notch extra-cellular domain Normal fibroblast Notch intra-cellular domain Non-progressive response rate No response Notch transmembrane domain Non-steroidal anti-inflammatory drug Objective response rate Overall survival Progression arrest rate Primary cell culture Progressive disease Phosphoinositide-dependent kinase Platelet Derived Growth Factor (Receptor) ɑ/ß Progression free survival Pleckstrin-homolog Phosphatidylinositol 3 Phosphatidylinositol 3-kinase Phosphatidylinositol (3,4,5)-triphosphate Partial response Patched 1 Phosphatase and tensin homolog deleted on chromosome ten (10) Receptor tyrosine kinase Stable disease Sonic hedgehog SMA- and MAD-related protein / SMAD Family member Smoothened Signal Transducer and Activator of Transcription Suppressor of fused homolog T-cell factor Transforming growth factor-ß Tyrosin kinase inhibitor Treatment stop Time to treatment failure Time to progress Vascular Endothelial Growth Factor Wild-type Wnt-1 Inducible Signaling pathway Protein 1 Wingless 2