Milea Timbergen

68 Figure 2B. Heat map depicting an unsupervised hierarchical cluster analysis of 93 desmoid-type fibroma- tosis samples harbouring T41A, S45F CTNNB1 mutations and wildtype tumours using selected the mRNA expression levels of a set of putative mesenchymal Wnt target genes. Red and green represent relatively high and low expression levels, respectively. Tumour status (primary or recurrent); tumours size (<40 mm, 40-69 mm, 70-104 mm, >104 mm); age at diagnosis presented in categories based on the median and the 25th and 75th percentiles (age < 27 years, 27-37 years 38-55 years and > 55 years); tumour site (intra-abdominal, extra-abdominal and abdominal wall); sex and CTNNB1 mutation status are indicated. 3