Milea Timbergen

86 Supplemental Figure 1A (part 1). Hierarchical clustering based on Wnt target mRNA expression in des- moid tumors does not discriminate wild-type, samples with an unknown CTNNB1 status, rare CTNNB1 mutants and CTNNB1 S45F, S45P, T41A mutants. Heat map depicting an unsupervised hierarchical cluster analysis of 128 desmoid-type fibromatosis samples harbouring T41A or S45F CTNNB1 mutations and wild- type tumours using the mRNA expression levels of selected mammalian Wnt target genes. Red and green represent relative high and low expresion levels, respectively. Tumour status (primary or recurrent); tumour size (<40 mm, 40-69 mm, 70-104 mm, >104 mm); age at diagnosis presented in categories based on the median and the 25th and 75th percentiles (age < 27 years, 27-37 years 38-55 years and > 55 years); tumour site (intra-abdominal, extra-abdominal and abdominal wall); sex and CTNNB1 mutation status are indicated. 3