Milea Timbergen

88 Supplemental Figure 1B. Hierarchical clustering based on Wnt target mRNA expression in desmoid tu- mours does not discriminate wild-type,samples with an unknown CTNNB1 status, rare CTNNB1 mutants and CTNNB1 S45F, S45P, T41A mutants. Heat map depicting an unsupervised hierarchical cluster analysis of 128 desmoid-type fibromatosis samples harbouring wild-type, CTNNB1 samples, samples with an un- known CTNNB1 status, samples with rare CTNNB1 mutations and CTNNB1 S45F, S45P, T41A mutants, using selected the mRNA expression levels of a set of putative mesenchymal Wnt target genes. Red and green represent relatively high and low expression levels, respectively. Tumour status (primary or recurrent); tumour size (<40 mm, 40-69 mm, 70-104 mm, >104 mm); age at diagnosis presented in categories based on the median and the 25th and 75th percentiles (age < 27 years, 27-37 years 38-55 years and > 55 years); tumour site (intra-abdominal, extra-abdominal and abdominal wall); sex and CTNNB1 mutation status are indicated. 3