Milea Timbergen

Chapter 1 General Introduction and Aims of this thesis	7
Chapter 2 Activated signalling pathways and targeted therapies in desmoid-type fibromatosis: A literature review	21
Chapter 3 Wnt target genes are not differentially expressed in desmoid tumours bearing different activating β-catenin mutations	57
Chapter 4 Differentially methylated regions in desmoid-type fibromatosis: A comparison between CTNNB1 S45F and T41A tumours	91
Chapter 5 Differential diagnosis and mutation stratification of desmoid-type fibromatosis on MRI using radiomics	123
Chapter 6 Active surveillance in desmoid-type fibromatosis: A systematic literature review	159
Chapter 7 The prognostic role of β-catenin mutations in desmoid-type fibromatosis undergoing resection only: A meta-analysis of individual patient data	185
Chapter 8 Identification and assessment of health-related quality of life issues in patients with sporadic desmoid-type fibromatosis: A literature review and focus group study	219
Chapter 9 Assessing the desmoid-type fibromatosis patients’ voice: Comparison of health-related quality of life experiences from patients of two countries	245
Chapter 11 General discussion	277
Chapter 12 Future perspectives	287
Chapter 13 Summary	295
Samenvatting	300
Contributing authors	308
About the author	312
PhD portfolio	313
List of publications	314
Dankwoord	316

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