Carolien Zeetsen

94 Table 5.2. Continued. Cognitive domain (range) Total AUD ( n = 166) ( n = 35) Orientation (0–6) T0 4.43 (1.72) 5.63 (0.73) T1 5.01 (1.27) 5.69 (0.63) T2 5.04 (1.35) 5.66 (0.64) p –value (post–hoc) < .001***††† (T0 < T1; T0 < T2††) Note: AUD = Alcohol Use Disorder; ARCI = Alcohol–Related Cognitive Impairments; KS = Korsakoff’s Syndrome; T0 = baseline/intake; T1 = after six weeks of clinical admission; T2 = at clinical discharge; † = Bonferroni; †† = Hochberg’s GT2; ††† = Greenhouse–Geisser; †††† = Games–Howell; * = p < .05; ** = p < .005; *** = p < .001. Course of everyday cognitive functioning Patient rating There was a significant main effect of time on overall everyday cognitive functioning (PCRS–TS; F (1, 297) = 8.30, p = .004, η 2 = 0.027), meaning that patients scored higher on T2 than on T1. No significant main effect of group nor a significant interaction was found. For the domain scores, significant main effects of time were found on ADL ( F (1, 297) = 9.26, p = .003, η 2 = 0.030), CO ( F (1, 297) = 4.02, p = .046, η 2 = 0.013) and EM ( F (1, 297) = 7.19, p = .008, η 2 = 0.023), where all scores improved. A significant main effect of group was found on CO ( F (1, 297) = 9.30, p < .001, η 2 = 0.059), where post–hoc tests revealed that patients with AUD scored significantly higher than those with ARCI ( M diff = 2.09, SD = 0.75, p =.017) and those with KS ( M diff = 3.48, SD = 0.81, p < .001). There were no significant interaction effects (see Table 5.3). Clinician rating There was a significant main effect of group on overall everyday cognitive functioning (PCRS–TS; F (2, 345) = 102.30, p < .001, η 2 = 0.372), where post–hoc tests revealed that patients with AUD scored higher than those with ARCI ( M diff = 7.69, SD = 2.25) and those with KS ( M diff = 29.59, SD = 2.41), and patients with ARCI scored higher than those with KS ( M diff = 21.89, SD = 1.80; all p –values < .005). No significant main effect of time nor a significant interaction effect was found for overall everyday cognitive functioning. Significant main effects of time were found on all domain scores (ADL: F (1, 345) = 15.68, p < .001, η 2 = 0.043; CO: F (1, 345) = 21.37, p < .001, η 2 = 0.058; IP F (1, 345) = 4.68, p = .031, η 2 = 0.013; EM: F (1, 345) = 21.81, p < .001, η 2 = 0.058) and significant main effects of group