Els van de Vijver

105 Figure 1 | Study flow diagram Forty-five percent (48/106) of participants were female. Thirty-nine percent (41/106) were aged 8 to 12 years, and 61% (65/106) were aged 13 to 18 years. Twenty-four percent (25/106) of the participants had ulcerative colitis, 73% (77/106) had Crohn’s disease, and 4% (4/106) had IBD-unclassified. Fifty-four percent (53/98) had disease activity scores indicating clinical remission, 45% (44/98) had mild disease activity and one participant had moderate disease activity. Fatigue prevalence The distribution of PedsQL TM total fatigue scores in patients with IBD was significantly lower compared to healthy peers (p<0.0001). In patients aged 8 to 12 years the mean fatigue Z-score was -0.9 (SD 1.3). In patients aged 12 to 18 years the mean fatigue Z-score was -1.1 (SD 1.4). IBD patients scored lower than healthy peers on all dimensions of the PedsQL TM fatigue scale. [Figure 2] Twenty-three patients (22%) had Z-scores below -2.0 and were considered fatigued. Self-reported fatigue and biological and functional parameters 105