Els van de Vijver

109 Quality-of-life Fatigued patients had lower median quality-of-life scores compared to non-fatigued IBD patients (120 (IQR 115 to 127) vs. 146 (IQR 134 to 157); p<0.0001) [ Figure 4 ]. Figure 4 | IMPACT-III quality-of-life scores in fatigued and non-fatigued patients. Central boxes span 25th and 75th centiles (or the interquartile range). Horizontal line within box represents median . DISCUSSION Key findings In this multicenter study we found that approximately a quarter of paediatric patients with quiescent to moderately active IBD qualified as fatigued. Interestingly, neither haemoglobin parameters nor faecal calprotectin nor the exercise capacity, expressed as the 6MWD, was significantly different between fatigued and non-fatigued IBD patients. Fatigued patients had a significantly lower quality-of-life scores and higher clinical activity indices, but otherwise this group did not differ in any respect from the non-fatigued patients. The mean total Z-score of the Child Self Report PedsQL TM Multidimensional Fatigue Scale in our study cohort (-1.0) was comparable with the total Z-score (-0.7) in a similarly aged American cohort of IBD patients described by Marcus and colleagues.(12) In this single center case-control study, IBD patients completed questionnaires about fatigue, quality- Self-reported fatigue and biological and functional parameters 109