Els van de Vijver

2 The research described in this thesis was performed at the Department of Pediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. The author gratefully acknowledges the financial support for printing this thesis by: Groningen University Institute for Drug Exploration (GUIDE) University Medical Center Groningen (UMCG) University of Groningen This thesis is printed by: Ridderprint BV, Ridderkerk, The Netherlands Cover: Ridderprint www.ridderprint.nl ISBN: 978-94-6416-226-4