Els van de Vijver

47 Figure 3 I Box- and whisker plot for calprotectin (A) and calgranulin-C (B) concentrations per diagnosis. Whiskers represent the 95% confidence interval. Number of cases in brackets. * The GI-infection group had either bacterial colon pathogens or G. lamblia. **The miscellaneous group included bile-salt diarrhoea (n=1), hemolytic uremic syndrome (n=1), mediterranean fever (n=1), fructose overload (n=1), spondylarthropathy (n=1), Hirschsprung’s disease (n=1) and allergic enterocolitis (n=1). The remaining 12 were “non-IBD, not otherwise specified”. Predefined thresholds Figure 4A shows the diagnostic accuracy measures based on predefined thresholds for calprotectin (50 μg/g) and calgranulin-C (0.75 μg/g), calculated with the Bayesian correction method. In this analysis calgranulin-C has significantly better specificity (97.3% (95% CI: 94.1 to 99.4) vs. 71.3% (CI: 63.3 to 79.0)) and better positive predictive value (92.7% (CI: 84.6 to Head-to-head comparison Calgranulin C and Calprotectin 47